Uni-Logo
ZHG-Logo
Zentrum für Humangenetik Bremen

Universität Bremen, Leobener Str. ZHG, D-28359 Bremen



Wir über uns Mitarbeiter Kontakt Genetische Beratung Diagnostik Forschung Publikationen Lehre Schulen
News Links Home Haftungsausschluss Impressum Research Disclaimer                
   


Publikationen
Publikationen der letzten 5 Jahre (Publications of the last 5 years)


Ältere Publikationen sind im Archiv zu finden.
Older publications may be found in the archive.

2012

  • Belge G, Dieckmann KP, Spiekermann M, Balks T, Bullerdiek J (2012). Serum levels of microRNAs miR-371-3: A novel class of serum biomarkers for testicular germ cell tumors? Eur Urol 61:1068-1069.

  • Klemke M, Drieschner N, Belge G, Burchardt K, Junker K, Bullerdiek J (2012). Detection of PAX8-PPARG fusion transcripts in archival thyroid carcinoma samples by conventional RT-PCR. Genes Chromosomes Cancer 51:402-408.

  • Markowski, DN, Helmke BM, Radtke A, Froeb J, Belge G, Bartnitzke S, Wosniok W, Czybulka-Jachertz I, Deichert U, Bullerdiek J (2012). Fibroid explants reveal a higher sensitivity against MDM2-inhibitor nutlin-3 than matching myometrium. BMC Womens Health 12: 2

  • Müller MH, Reimann-Berg N, Bullerdiek J, Murua Escobar H (2012). Genetic characterization of dogs via chromosomal analysis and array-based comparative genomic hybridization (aCGH). Tierärztl Prax Ausg K Kleintiere Heimtiere 40:55-58.

  • Sendt W, Rippe V, Flor I, Drieschner N, Bullerdiek J (2012). Monosomy and ring chromosome 13 in a thyroid nodular goiter-do we underestimate its relevance in benign thyroid lesions? Cancer Genet 205:128-130.

  • Willenbrock S, Braun O, Baumgart J, Lange S, Junghanss C, Heisterkamp A, Nolte I, Bullerdiek J, Murua Escobar H (2012)(online 2011). TNF-α induced secretion of HMGB1 from non-immune canine mammary epithelial cells (MTH53A). Cytokine 57:210-220.


2011

  • Belge G, Radtke A, Meyer A, Stegen I, Richardt D, Nimzyk R, Nigam V, Dendorfer A, Sievers HH, Tiemann M, Buchwalow I, Bullerdiek J, Mohamed SA (2011). Upregulation of the high mobility group AT-hook 2 gene in acute aortic dissection is potentially associated with endothelial-mesenchymal transition. Histol Histopathol 26:1029-1037.

  • Bullerdiek J, Müsebeck J (2011). Prädiktive Diagnostik erblicher Tumordispositionen. Bremer Ärztejournal 64:13-14.

  • Drieschner N, Rippe V, Laabs A, Dittberner L, Nimzyk R, Junker K, Rommel B, Kiefer Y, Belge G, Bullerdiek J, Sendt W (2011). Interphase fluorescence in situ hybridization analysis detects a much higher rate of thyroid tumors with clonal cytogenetic deviations of the main cytogenetic subgroups than conventional cytogenetics. Cancer Genet 204:366-374.

  • Helmke BM, Markowski, DN, Müller MH, Sommer A, Müller J, Möller C, Bullerdiek J (2011). HMGA proteins regulate the expression of FGF2 in uterine fibroids.  Mol Hu. Repro 17:135-142.

  • Klemke M, Drieschner N, Laabs A, Rippe V, Belge G, Bullerdiek J, Sendt W (2011). On the prevalence of the PAX8-PPARG fusion resulting from the chromosomal translocation t(2;3)(q13;p25) in adenomas of the thyroid. Cancer Genet 204:334-339.

  • Kloth L, Belge G, Burchardt K, Loeschke S, Wosniok W, Fu X, Mohamed SA, Drieschner N, Rippe V, Bullerdiek J (2011). Decrease in thyroid adenoma associated (THADA) expression is a marker of dedifferentiation of thyroid tissue. BMC Clin Pathol 11:13.

  • Markowski DN, Helmke BM,  Belge G, Nimzyk R, Bartnitzke S, Deichert U, Bullerdiek J. (2011). HMGA2 and p14Arf: Major roles in cellular senescence of fibroids and therapeutic implications. Anticancer Res 31:753-761.

  • Markowski DN, Helmke BM, Meyer F, von Ahsen I, Nimzyk R, Nolte I, Bullerdiek J (2011). BMP4 increases expression of HMGA2 in mesenchymal stem cells. Cytokine 56:811-816.

  • Markowski, DN, Winter N, Meyer F, von Ahsen I, Wenk H, Nolte I, Bullerdiek J (2011). p14(Arf) acts as an antagonist of HMGA2 in senescence of mesenchymal stem cells-implications for benign tumorigenesis. Genes Chromosomes Cancer 50:489-498.

  • Reimann-Berg N, Murua Escobar H, Kiefer Y, Mischke R, Willenbrock S, Eberle N, Nolte I, Bullerdiek J (2011). Cytogenetic analysis of CpG-oligonucleotide DSP30 plus Interleukin-2-stimulated canine B-Cell lymphoma cells reveals the loss of one X chromosome as the sole abnormality.Cytogenet Genome Res 135:79-82. 

  • Reimann-Berg N, Willenbrock S, Murua Escobar H, Eberle N, Gerhauser I, Mischke R, Bullerdiek J, Nolte I (2011). Two new cases of polysomy 13 in canine prostate cancer. Cytogenet Genome Res 132:16-21.

  • Richter A, Lübbing M, Frank H-G, Nolte I, Bullerdiek J, von Ahsen I (2011). High-mobility group protein HMGA2-derived fragments stimulate the proliferation of chondrocytes and adipose tissue-derived stem cells. Eur Cell Mater 21:355-363.

  • Sterenczak KA, Kleinschmidt S, Wefstaedt P, Eberle N, Hewicker-Trautwein M, Bullerdiek J, Nolte I, Murua Escobar H (2011). Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (malignant histiocytosis). Anticancer Res 31: 1541-1548.

  • Winter N, Nimzyk R, Bösche C, Meyer A, Bullerdiek J. (2011). Chromatin immunoprecipitation to analyze DNA binding sites of HMGA2. PLoS One 6: e18837.  


2010
  • Bullerdiek J, Rommel B (2010). Comment Re: HMGA2 is a negative regulator of DNA-PK pathway. Cancer Res. 10:1742.

  • Gentschev I, Ehrig K, Donat U, Hess M, Rudolph S, Chen N, Yu YA, Zhang Q, Bullerdiek J, Nolte I, Stritzker J, Szalay AA(2010). Significant growth inhibition of canine mammary carcinoma xenografts following treatment with oncolytic vaccinia virus GLV-1h68. J Oncol 2010:736907.

  • Hashemi Nezhad M, Drieschner N, Helms S, Meyer A, Tadayyon M, Klemke M, Belge G, Bartnitzke S, Burchardt K, Frantzen C, Schmidt EH, Bullerdiek J (2010). 6p21 rearrangements in uterine leiomyomas targeting HMGA1. Cancer Genet Cytogenet 203:247-252.

  • Joetzke AE, Sterenczak KA, Eberle N, Wagner S, Soller JT, Nolte I, Bullerdiek J, Murua Escobar H, Simon D (2010). Expression of the high mobility group A1 (HMGA1) and A2 (HMGA2) genes in canine lymphoma: analysis of 23 cases and comparison to control cases.Vet Comp Oncol 8:87-95.

  • Kiefer Y, Drieschner N, Förster H, Tiemann M, Schulte C, Rommel B, Bullerdiek J (2010). An unbalanced t(15;18)(q21-q22;p11) as the sole cytogenetic aberration in a patient with B-cell chronic lymphocytic leukemia.Cancer Genet Cytogenet 200:65-69.

  • Klemke M, Meyer A, Hashemi Nezhad M, Belge G, Bartnitzke S, Bullerdiek J (2010). Loss of let-7 binding sites resulting from truncations of the 3' untranslated region of HMGA2 mRNA in uterine leiomyomas. Cancer Genet. Cytogenet 196:119-123.

  • Markowski DN, Bartnitzke S, Belge G, Drieschner N, Helmke BM, Bullerdiek J (2010). Cell culture and senescence in uterine fibroids.Cancer Genet Cytogenet 202:53-57.

  • Markowski DN, Helmke BM, Bullerdiek J (2010). Cellular senescence in usual type uterine leiomyoma. Fertil Steril 94: e79.

  • Markowski DN, von Ahsen I, Hashemi Nezhad M, Wosniok W, Helmke BM, Bullerdiek J (2010). HMGA2 and the p19Arf-TP53-CDKN1A axis: a delicate balance in the growth of uterine leiomyomas.Genes Chromosomes Cancer 49:661-668.

  • Meyer A, Eberle N, Bullerdiek J, Nolte I, Simon D (2010). High-mobility group B1 proteins in canine lymphoma: prognostic value of initial and sequential serum levels in treatment outcome following combination chemotherapy.Vet Comp Oncol 8:127-137.

  • Mohamed SA, Misfeld M, Hanke T, Charitos EI, Bullerdiek J, Belge G, Kuehnel W, Sievers HH (2010). Inhibition of caspase-3 differentially affects vascular smooth muscle cell apoptosis in the concave versus convex aortic sites in ascending aneurysms with a bicuspid aortic valve.Ann Anat. 192:145-150.

  • Rippe V, Dittberner L, Lorenz VN, Drieschner N, Nimzyk R, Sendt W, Junker K, Belge G, Bullerdiek J (2010). The two stem cell microRNA gene clusters C19MC and miR-371-3 are activated by specific chromosomal rearrangements in a subgroup of thyroid adenomas.PLoS One 5:e9485.

  • Sterenczak KA, Joetzke AE, Willenbrock S, Eberle N, Lange S, Junghanss C, Nolte I, Bullerdiek J, Simon D, Murua Escobar H. (2010 ). High-mobility group B1 (HMGB1) and receptor for advanced glycation end-products (RAGE) expression in canine lymphoma. Anticancer Res 30:5043-5048.


2009

  • Bullerdiek J, Helmke BM (2009). Comment on 'HMGA2, MicroRNAs, and Stem Cell Aging'. Cell Online Comment

  • Fehr A, Meyer A, Heidorn K, Röser K, Löning T, Bullerdiek J (2009). A link between the expression of the stem cell marker HMGA2, grading, and the fusion CRTC1-MAML2 in mucoepidermoid carcinoma. Genes Chromosomes Cancer 48:777-785.

  • Fehr A, Stenman G, Bullerdiek J, Löning T (2009). Molecular markers in salivary gland tumors: Their use in diagnostic and prognostic workup. Pathologe 30:466-471.

  • Gentschev I, Stritzker J, Hofmann E, Weibel S, Yu YA, Chen N, Zhang Q, Bullerdiek J, Nolte I, Szalay AA (2009)(online 2008). Use of an oncolytic vaccinia virus for the treatment of canine breast cancer in nude mice: preclinical development of a therapeutic agent. Cancer Gene Ther 16:320-328.

  • Hauschild G, Muschter N, Richter A, Ahrens H, Gosheger G, Fehr M, Bullerdiek J (2009). Cartilage replacement in dogs. Vet Comp Orthop Traumatol 22:216-221.

  • Klemke M, Meyer A, Hashemi Nezhad M, Bartnitzke S, Drieschner N, Frantzen C, Schmidt E-H, Belge G, Bullerdiek J (2009)(online 2008). Overexpression of HMGA2 in uterine leiomyomas points to its general role for the pathogenesis of the disease. Genes Chromosomes Cancer 48:171-178. 

  • Lacbawan F, Solomon BD, Roessler E, El-Jaick K, Domené S, Vélez JI, Zhou N, Hadley D, Balog JZ, Long R, Fryer A, Smith W, Omar S, McLean SD, Clarkson K, Lichty A, Clegg NJ, Delgado MR, Levey E, Stashinko E, Potocki L, Vanallen MI, Clayton-Smith J, Donnai D, Bianchi DW, Juliusson PB, Njølstad PR, Brunner HG, Carey JC, Hehr U, Müsebeck J, Wieacker PF, Postra A, Hennekam RC, van den Boogaard MJ, van Haeringen A, Paulussen A, Herbergs J, Schrander-Stumpel CT, Janecke AR, Chitayat D, Hahn J, McDonald-McGinn DM, Zackai EH, Dobyns WB, Muenke M (2009). Clinical spectrum of SIX3-associated mutations in holoprosencephaly: correlation between genotype, phenotype and function. J Med Genet 46:389-398.

  • Mohamed SA, Sievers HH, Hanke T, Richardt D, Schmidtke C, Charitos EI, Belge G, Bullerdiek J (2009). Pathway analysis of differentially expressed genes in patients with acute aortic dissection. Biomark Insights 4:81-90.

  • Pavlova A, Brondke H, Müsebeck J, Pollmann H, Srivastava A, Oldenburg J (2009). Molecular mechanisms underlying hemophilia A phenotype in seven females. J Thromb Haemost 7:976-982.

  • Petersen S, Soller JT, Wagner S, Richter A, Bullerdiek J, Nolte I, Barcikowski S, Murua Escobar H (2009). Co-transfection of plasmid DNA and laser-generated gold nanoparticles does not disturb the bioactivity of  GFP-HMGB1 fusion protein. J Nanobiotechnology 7:6.

  • Richter A, Hauschild G, Murua Escobar H, Nolte I, Bullerdiek J (2009)(online 2008). Application of high-mobility-group-A proteins increases the proliferative activity of chondrocytes in vitro. Tissue Eng  Part A 15:473-477.

  • Sterenczak KA, Willenbrock S, Barann M, Klemke M, Soller JT, Eberle N, Nolte I, Bullerdiek J, Murua Escobar H (2009)(online 2008). Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms. Gene 434:35-42.

  • Verdorfer I, Fehr A, Bullerdiek J, Scholz N, Brunner A, Krugmann J, Hager M, Haufe H, Mikuz G, Scholtz A (2009). Chromosomal imbalances, 11q21 rearrangement and MECT1-MAML2 fusion transcript in mucoepidermoid carcinomas of the salivary gland. Oncol Rep 22:305-11.

  • Winter N, Meyer A, Richter A, Krisponeit D, Bullerdiek J (2009). Elevated levels of HMGB! in cancerous and inflammatory effusions. Anticancer Res 29:5013-5017.
2008

  • Altmann S, Lange S, Pommerencke J, Murua Escobar H, Bullerdieck J, Nolte I, Freund M, Junghanss C (2008). High Mobility Group Box 1-Protein expression in canine haematopoietic cells and influence on canine peripheral blood mononuclear cell proliferative activity. Vet Immunol Immunpathol 126:367-372.

  • Belge G, Meyer A, Klemke M, Burchardt K, Stern C, Wosniok W, Loeschke S, Bullerdiek J (2008).Upregulation of HMGA2 in thyroid carcinomas: A novel molecular marker to distinguish between benign and malignant follicular neoplasias. Genes Chromosomes Cancer 47:56-63.

  • Beuing C, Soller JT, Muth M, Wagner S, Dolf G, Schelling C, Richter A, Willenbrock S, Reimann-Berg N, Winkler S, Nolte I, Bullerdiek J, Murua Escobar H (2008). Genomic characterisation, chromosomal assignment and in vivo localisation of the canine high mobility group A1 (HMGA1) gene. BMC Genet 9:49.

  • Fehr A, Röser K, Heidorn K, Hallas C, Löning T, Bullerdiek J (2008). A new type of MAML2 fusion in mucoepidermoid carcinoma. Genes Chromosomes Cancer 47:203-206.

  • Fehr A, Röser K, Belge G, Löning T, Bullerdiek J (2008). A closer look at Warthin tumors and the t(11;19). Cancer Genet Cytogenet 180:135-139.

  • Fork MAM, Murua Escobar H, Soller JT, Sterenczak KA, Willenbrock S, Winkler S, Dorsch M, Reimann-Berg N, Hedrich HHJ, Bullerdiek J, Nolte I (2008). Establishing an in vivo model of canine prostate carcinoma using the new cell line CT1258. BMC Cancer 8:240.

  • Hafner C, Vogt T, Landthaler M, Müsebeck J (2008). FGFR3 and PIK3CA mutations are present in familial seborrheic keratoses. Br J Dermatol 159: 214-217.

  • Meyer A, Staratschek-Jox A, Springwald A, Wenk H, Wolf J, Wickenhauser C, Bullerdiek J (2008). Non-Hodgkin lymphoma expressing high levels of the danger-signalling protein HMGB1. Leuk Lymphoma 49:1184-1189.

  • Reimann-Berg N, Murua Escobar H, Nolte I, Bullerdiek J (2008). Testicular tumor in an XXY dog. Cancer Genet Cytogenet 183:114-116.

  • Soller JT, Beuing C, Murua Escobar H, Winkler S, Reimann-Berg N, Drieschner N, Dolf G, Schelling C, Nolte I, Bullerdiek J (2008).Chromosomal assignment of canine THADA gene to CFA 10q25.Mol Cytogenet 1:11.

  • Von Ahsen I, Nimzyk R, Klemke M, Bullerdiek J (2008). A microRNA encoded in a highly conserved part of the mammalian HMGA2 gene. Cancer Genet Cytogenet 187:43-44.

  • Winter N, Neumann A, Bullerdiek J (2008). Cell-free DNA in amniotic fluid remains to be attached to HMGA2 - implications for non-invasive prenatal diagnosis. Prenat Diagn 28:1126-1130.



Top